Effects of propofol, etomidate, midazolam, and fentanyl on motor evoked responses to transcranial electrical or magnetic stimulation in humans.
Identifieur interne : 004732 ( Main/Exploration ); précédent : 004731; suivant : 004733Effects of propofol, etomidate, midazolam, and fentanyl on motor evoked responses to transcranial electrical or magnetic stimulation in humans.
Auteurs : C J Kalkman [États-Unis] ; J C Drummond ; A A Ribberink ; P M Patel ; T. Sano ; R G BickfordSource :
- Anesthesiology [ 0003-3022 ] ; 1992.
Descripteurs français
- KwdFr :
- MESH :
- pharmacologie : Fentanyl, Midazolam, Propofol, Étomidate.
- Adulte, Femelle, Humains, Injections veineuses, Magnétisme, Muscles, Mâle, Potentiels évoqués, Stimulation électrique.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Etomidate, Fentanyl, Midazolam, Propofol.
- drug effects : Evoked Potentials, Muscles.
- Adult, Electric Stimulation, Female, Humans, Injections, Intravenous, Magnetics, Male.
Abstract
The effects of propofol, etomidate, midazolam, and fentanyl on motor evoked responses to transcranial stimulation (tc-MERs) were studied in five healthy human volunteers. Each subject, in four separate sessions, received intravenous bolus doses of propofol 2 mg.kg-1, etomidate 0.3 mg.kg-1, midazolam 0.05 mg.kg-1, and fentanyl 3 micrograms.kg-1. Electrical tc-MERs (tce-MERs) were elicited with anodal stimuli of 500-700 V. Magnetic tc-MERs (tcmag-MERs) were elicited using a Cadwell MES-10 magnetic stimulator at maximum output. Compound muscle action potentials were recorded from the tibialis anterior muscle. Duplicate tce-MERs and tcmag-MERs were recorded before and up to 30 min after drug injection. Reproducible baseline tce-MERs (amplitude 4.7 +/- 0.43 (SEM) mV, latency 29.4 +/- 0.35 ms) and tcmag-MERs (amplitude 3.7 +/- 0.43 mV, latency 31.1 +/- 0.39 ms) were obtained in all subjects. Pronounced depression of tce-MER amplitude to 2% of baseline values (P less than 0.01) was observed 2 min after injection of propofol. Thirty minutes after injection of propofol, amplitude depression to 44% of baseline (P less than 0.05) was still present, despite an apparent lack of sedation. Midazolam caused significant (P less than 0.01) amplitude depression, e.g., tcmag-MER to 16% of baseline values 5 min after injection. Significant depression persisted throughout the 30-min study period. Fentanyl did not cause any statistically significant amplitude changes in this small population. Etomidate caused significant but transient depression of tc-MER amplitude. However, there was considerable intersubject variability. Latency did not change significantly after any drug.(ABSTRACT TRUNCATED AT 250 WORDS)
DOI: 10.1097/00000542-199204000-00003
PubMed: 1550274
Affiliations:
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Sano</name></author><author><name sortKey="Bickford, R G" sort="Bickford, R G" uniqKey="Bickford R" first="R G" last="Bickford">R G Bickford</name></author></analytic><series><title level="j">Anesthesiology</title><idno type="ISSN">0003-3022</idno><imprint><date when="1992" type="published">1992</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Electric Stimulation</term><term>Etomidate (pharmacology)</term><term>Evoked Potentials (drug effects)</term><term>Female</term><term>Fentanyl (pharmacology)</term><term>Humans</term><term>Injections, Intravenous</term><term>Magnetics</term><term>Male</term><term>Midazolam (pharmacology)</term><term>Muscles (drug effects)</term><term>Propofol (pharmacology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Femelle</term><term>Fentanyl (pharmacologie)</term><term>Humains</term><term>Injections veineuses</term><term>Magnétisme</term><term>Midazolam (pharmacologie)</term><term>Muscles ()</term><term>Mâle</term><term>Potentiels évoqués ()</term><term>Propofol (pharmacologie)</term><term>Stimulation électrique</term><term>Étomidate (pharmacologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Etomidate</term><term>Fentanyl</term><term>Midazolam</term><term>Propofol</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Evoked Potentials</term><term>Muscles</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Fentanyl</term><term>Midazolam</term><term>Propofol</term><term>Étomidate</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Electric Stimulation</term><term>Female</term><term>Humans</term><term>Injections, Intravenous</term><term>Magnetics</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Femelle</term><term>Humains</term><term>Injections veineuses</term><term>Magnétisme</term><term>Muscles</term><term>Mâle</term><term>Potentiels évoqués</term><term>Stimulation électrique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The effects of propofol, etomidate, midazolam, and fentanyl on motor evoked responses to transcranial stimulation (tc-MERs) were studied in five healthy human volunteers. Each subject, in four separate sessions, received intravenous bolus doses of propofol 2 mg.kg-1, etomidate 0.3 mg.kg-1, midazolam 0.05 mg.kg-1, and fentanyl 3 micrograms.kg-1. Electrical tc-MERs (tce-MERs) were elicited with anodal stimuli of 500-700 V. Magnetic tc-MERs (tcmag-MERs) were elicited using a Cadwell MES-10 magnetic stimulator at maximum output. Compound muscle action potentials were recorded from the tibialis anterior muscle. Duplicate tce-MERs and tcmag-MERs were recorded before and up to 30 min after drug injection. Reproducible baseline tce-MERs (amplitude 4.7 +/- 0.43 (SEM) mV, latency 29.4 +/- 0.35 ms) and tcmag-MERs (amplitude 3.7 +/- 0.43 mV, latency 31.1 +/- 0.39 ms) were obtained in all subjects. Pronounced depression of tce-MER amplitude to 2% of baseline values (P less than 0.01) was observed 2 min after injection of propofol. Thirty minutes after injection of propofol, amplitude depression to 44% of baseline (P less than 0.05) was still present, despite an apparent lack of sedation. Midazolam caused significant (P less than 0.01) amplitude depression, e.g., tcmag-MER to 16% of baseline values 5 min after injection. Significant depression persisted throughout the 30-min study period. Fentanyl did not cause any statistically significant amplitude changes in this small population. Etomidate caused significant but transient depression of tc-MER amplitude. However, there was considerable intersubject variability. Latency did not change significantly after any drug.(ABSTRACT TRUNCATED AT 250 WORDS)</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region><settlement><li>San Diego</li></settlement></list><tree><noCountry><name sortKey="Bickford, R G" sort="Bickford, R G" uniqKey="Bickford R" first="R G" last="Bickford">R G Bickford</name><name sortKey="Drummond, J C" sort="Drummond, J C" uniqKey="Drummond J" first="J C" last="Drummond">J C Drummond</name><name sortKey="Patel, P M" sort="Patel, P M" uniqKey="Patel P" first="P M" last="Patel">P M Patel</name><name sortKey="Ribberink, A A" sort="Ribberink, A A" uniqKey="Ribberink A" first="A A" last="Ribberink">A A Ribberink</name><name sortKey="Sano, T" sort="Sano, T" uniqKey="Sano T" first="T" last="Sano">T. Sano</name></noCountry><country name="États-Unis"><region name="Californie"><name sortKey="Kalkman, C J" sort="Kalkman, C J" uniqKey="Kalkman C" first="C J" last="Kalkman">C J Kalkman</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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